Hitting KRAS When It's Down | Journal of Medicinal Chemistry

Hitting KRAS When It's Down | Journal of Medicinal Chemistry

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Hitting KRAS When It's Down | Journal of Medicinal Chemistry

22 Jun 2020 ... (B) Cocrystal structures of KRASG12C in complex with the various binders show the highly similar binding modes of these compounds. No ...

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The beginning of the end for KRAS cancers | boehringer-ingelheim ...

29 Oct 2019 ... As yet, there are no drugs approved against RAS proteins, of which ... the KRAS signalling is shut down at the drug target and the 'volume' of ...

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Abstract A26: Precise characterization and comparison of KRAS ...

1 May 2020 ... ... and comparison of KRAS proteoforms by top-down mass spectrometry ... KRAS4A, which not only exhibits differential PTM to KRAS4B, but varies widely in both ... Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL.

Down-regulation of KRAS-interacting miRNA-143 predicts poor ...

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ing away paraffin blocks with tumor tissue for KRAS mutation testing may not be ... In summary, the pathologists looking down ... e-mail: [email protected].

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STK33 kinase inhibitor BRD-8899 has no effect on KRAS ...

9 Feb 2012 ... STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability ... Knock down of STK33 was reported to induce apoptosis in ... HTRF Transcreener ADP assay was purchased from Cis-bio US ...

Dispatch Ras GTPases: Codon Bias Holds KRas Down but Not Out

7 Jan 2013 ... Ras GTPases: Codon Bias Holds KRas Down but Not Out ... B.M. Willumsen, A. Christensen, N.L. Hubbert, A.G. Papageorge, D.R. LowyThe ...

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